Most slicers work natively on Linux. I’ve used orca slicer and lychee in just past 24h.
As for modeling software freecad, blender obviously; onshape is browser based, so it should work; fusion360 is hard to get running, but from what I’ve heard it’s doable;
SOLIDWORKS can run in wine, but just barely - I’ve found it easier and more pleasant to run it in a windows vm
It’s always effort vs risk.
Since it’s a do once and forget kind of thing I’d rate effort rather low.
As for risk in the worst case scenario a single service being compromised means all of them are with the attacker getting access to everything those services can access, including all the credentials. Will you make an effort to be on top of all the updates for all services?
As far as I’m concerned: At home all containers for each service get a separate user. At work every container does.
To be fair it doesn’t run that great on Windows either.